TCR


Protocolnummer:
NL37327.000.11

Ziekenhuizen:
NKI / A.v.L ziekenhuis Amsterdam

Titel:
Multicenter phase l/lla study using t-cell receptor gene therapy in metastatic melanoma

Behandeling:
Adoptive therapy with T-cell receptor reactive lymphocytes

Stadium:
Stadium irresectable IIIc/IV

Belangrijkste in/exclusiecriteria:
In: inoperable stage lllc or IV cutaneous melanoma progressing after at least two lines of therapy (DTIC,BRAF, Ipilimumab),HLA-A*0201 positive, Primaty tumor and/or metastasis have to be positive for MART-1 (>10% of tumor cells),clinical performance status of ECOG. Ex: requirement for systemic steroid therapy, history of more than two CNS metastases, CNS lesions greater than 1 cm of show significant edema on the MRI scan until treated and demonstrate no clinical or radiologic CNS progression for at least 2 months.

Contactpersoon:
Prof. dr. J. Haanen

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