ACT plus vaccination


Protocolnummer:

Ziekenhuizen:
Leids Universitair Medisch Centrum

Titel:
Adoptive t- cell therapy plus vaccination in metastatic melanoma patients

Behandeling:
Melanoma-reactive T cells (ACT) plus low dose IFN-alpha followed by autologous whole tumor cell vaccine

Stadium:
Stadium irresectable IIIc/IV

Belangrijkste in/exclusiecriteria:
In: Melanoma must be one of the following: 1- Irresectable (or residual) regional metastatic melanoma or, 2- stage IV i.e. distant metastatic disease (any T, any N, M1a, M1b or M1c) and normal LDH. Presence of measurable progressive disease, negative for HIV, HBV and no anibodies against HCV. Ex: patients with brain metastases who are neurologically unstable/ on use of dexamethasone, clinically significant heart disease (NYHA Class lll or IV), active immunodefieciency disease.

Contactpersoon:
Dr. H. Kapiteijn

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