ACT plus vaccination
Protocolnummer:
Ziekenhuizen:
Leids Universitair Medisch Centrum
Titel:
Adoptive t- cell therapy plus vaccination in metastatic melanoma patients
Behandeling:
Melanoma-reactive T cells (ACT) plus low dose IFN-alpha followed by autologous whole tumor cell vaccine
Stadium:
Stadium irresectable IIIc/IV
Belangrijkste in/exclusiecriteria:
In: Melanoma must be one of the following: 1- Irresectable (or residual) regional metastatic melanoma or, 2- stage IV i.e. distant metastatic disease (any T, any N, M1a, M1b or M1c) and normal LDH. Presence of measurable progressive disease, negative for HIV, HBV and no anibodies against HCV. Ex: patients with brain metastases who are neurologically unstable/ on use of dexamethasone, clinically significant heart disease (NYHA Class lll or IV), active immunodefieciency disease.
Contactpersoon:
Dr. H. Kapiteijn